Exosomes for Hair & Scalp

Core functional proteins: IL-10, TGF-β3, EGF, filaggrin, loricrin, HSP70, lactoferrin, SOD

Targets: Damaged scalp keratinocytes, peri-follicular macrophages/immune cells, sebaceous epidermal cells

1. IL-10 + TGF-β3 inhibit the NF-κB pathway, down-regulating the factors behind persistent scalp redness, itching and pain.
2. Drive macrophages from pro-inflammatory M1 to reparative M2, breaking the chronic scalp-sensitivity cycle.
3. EGF promotes keratinocyte proliferation and up-regulates filaggrin and loricrin to rebuild the scalp brick-and-mortar structure, reducing water loss.
4. HSP70 stabilises cell membranes and SOD clears irritation-induced free radicals, easing stinging after acid peels or colouring/perming.
5. Lactoferrin suppresses over-growth of harmful scalp microbes, reducing inflammatory dandruff.

Core functional proteins: TGF-β2, PDGF, antimicrobial peptides, glutathione (GSH), HAS, lipid-metabolism regulators

Targets: Scalp sebaceous cells, scalp keratinocytes, scalp microbial colonisation areas

1. TGF-β2 down-regulates the sebaceous lipid-synthesis pathway, reducing triglyceride and sebum over-secretion for lasting oil control without over-drying.
2. Natural antimicrobial peptides inhibit Malassezia over-growth, cutting oily dandruff at the source.
3. GSH neutralises rancid free radicals from oil oxidation, improving scalp odour.
4. HAS regulates scalp oil–water balance and boosts stratum-corneum water storage, improving an oily-but-dehydrated scalp.
5. Rebuilds the scalp’s weakly-acidic microbiome and keeps beneficial flora stable, reducing recurrent oiliness and dandruff.

Core functional proteins: Wnt3a/Wnt10b, bFGF, VEGF, PDGF, TGF-β1, DHT antagonists, BMP inhibitors, fibronectin, type I/III procollagen

Targets: Bulge-region follicle stem cells, dermal-papilla (DP) cells, peri-follicular dermal microvasculature, follicle interstitial fibroblasts

1. Wnt-family proteins activate the core Wnt/β-catenin growth pathway and inhibit the dormancy factor Dkk1, waking resting follicle stem cells and pushing follicles from telogen into anagen.
2. VEGF promotes peri-follicular microvascular regeneration, delivering oxygen and nutrients to the dermal papilla and reversing follicle miniaturisation.
3. DHT antagonists block dihydrotestosterone damage to the dermal papilla, improving androgenetic hair loss.
4. bFGF + PDGF promote dermal-papilla proliferation and synthesise collagen and fibronectin, thickening the follicle base so new hair grows thicker and stronger.
5. Down-regulate chronic peri-follicular inflammation to prevent immune attack on follicles (improving alopecia areata) and prolong the growth phase.

Core functional proteins: Hydrolysed keratin, keratin cross-linking enzymes, TGF-β3, elastin, fibronectin, SOD, laminin

Targets: Open damaged cuticle, keratin-deficient cortex areas, hair-shaft medulla gaps

1. Releases keratin and cross-linking enzymes to fill cortical protein voids and repair broken disulphide bonds, improving tensile toughness and reducing breakage and split ends.
2. Laminin closes lifted cuticle scales, locking in internal moisture and improving dryness and frizz.
3. Elastin rebuilds the hair-shaft support structure, improving fine, flat hair and adding volume.
4. SOD clears oxidative damage from UV and hot air, slowing hair ageing and yellowing.

Core functional proteins: TGF-β1/3, bFGF, VEGF, MMP inhibitors, HSP70, collagen synthase, glutathione

Targets: Scalp dermal fibroblasts, the dermal–epidermal junction (DEJ), aged atrophic follicles, scalp melanocytes

1. The TGF-β pathway drives fibroblasts to synthesise type I/III collagen and elastic fibres, thickening the dermis, firming a loose scalp and softening scalp dry lines.
2. MMP inhibitors block collagen-degrading metalloproteinases, reducing dermal collagen loss and slowing scalp sagging.
3. VEGF improves overall scalp microcirculation, easing sallowness, dullness and poor oxygenation.
4. HSP70 repairs UV-induced cellular DNA damage and antioxidant action suppresses scalp pigment dullness.
5. Simultaneously nourishes aging follicles, delaying premature atrophy and shedding to keep the scalp youthful.

Core functional proteins: EGF, IL-10, TGF-β3, lactoferrin, keratin-repair peptides, HAS, glutathione, fibronectin

Targets: Chemically-burned scalp, post-procedure wound keratinocytes, severely damaged hair shafts, inflamed sebaceous glands

1. EGF speeds healing of wounds and chemically-damaged keratin, shortening the redness-and-stinging period after bleaching/colouring.
2. IL-10 quickly suppresses the intense inflammation from chemical irritation, calming and de-reddening.
3. Keratin peptides deeply repair cortical protein lost to bleaching, repairing severe split ends and breakage.
4. GSH neutralises the strong oxidative damage from peroxide and alkaline dye agents, preventing scalp yellowing and brittle, dry hair.
5. Fibronectin builds a scalp-wound repair scaffold, reducing post-transplant redness, scabbing and irritation-induced shedding; HAS repairs the barrier and hair-shaft moisture-locking, easing post-colour dryness and itch.