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Exosomes for Skin

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Application · Skin

Skin — efficacy & protocols

Medical-aesthetic exosome preparations for the face — barrier repair, hydration, brightening, whitening, anti-aging and acne-mark recovery, with clear onset timelines and usage guidance.

As MYS-Exo’s advanced engineered achievement in the facial field, our MYS-Exo skin products use 3D directional-loading technology to reach top-level enrichment of the key signals for skin repair. Through molecular modification of both the regenerative and anti-inflammatory pathways, they focus on calming facial micro-environment fluctuations at the cellular source and accelerating tissue restructuring — a professional-grade engineered solution for deep aging and a compromised barrier.

  • Inflammation Noise-Reduction (Anti-Inflammatory Engineering): Directionally boosting the exosome payload of endogenous inhibitory factors to precisely block the inflammatory signaling cascade, building a quiet, stable, healthy foundation and improving skin tolerance and self-repair.
  • Source-Driven Regeneration (Regenerative Engineering): High-payload enrichment of key regenerative factors directly activates the endogenous repair instructions of fibroblasts and basal cells, accelerating collagen reconstruction and extracellular-matrix renewal.
  • Barrier Reconstruction (Structural Engineering): Leveraging the transmembrane delivery of engineered exosomes to strengthen the dermal-epidermal junction (DEJ), improving epidermal tightness and water-locking and reshaping refined, firm skin with rapid downtime conversion.

Skin Barrier Repair

Repair damaged skin barrier, soothe redness, itching and inflammation, strengthen skin tolerance, ideal for sensitive skin and post-procedure care

10–30 mins

Relieve stinging, itching and redness immediately

3–7 days

Redness and irritation fade, skin gets stable

2–4 weeks

Skin barrier fully recovered, less prone to sensitivity

How to use: Use twice daily. Avoid alcohol, acid and irritating ingredients when applying.

Targeting principle & mechanism

Anti-acne & anti-inflammatory

Core functional proteins: IL-10, TGF-β3, HSP70, lactoferrin, SOD, PDGF, IL-4

Targets: Inflamed acne sebaceous glands, macrophages, red swollen pustular areas

  1. Inhibits the NF-κB pathway and down-regulates pro-inflammatory factors for rapid de-reddening and de-swelling.
  2. Drives macrophages from pro-inflammatory M1 to reparative M2, breaking the inflammation cycle.
  3. Suppresses C. acnes proliferation and unclogs blocked sebaceous glands.
  4. Clears inflammatory free radicals, easing burning and stinging.

Soothing & sensitivity repair

Core functional proteins: IL-10, TGF-β, HSP90, E-cadherin, profilaggrin

Targets: Sensitive damaged keratinocytes, immune cells, barrier-broken areas

  1. Down-regulates inflammatory signalling at skin nerve endings, lowering sensitivity and easing itching, burning and redness.
  2. Suppresses over-active immune responses, improving steroid-damaged skin, post-acid stinging and seasonal redness.
  3. Heat-shock proteins stabilise cell membranes, reducing damage from external irritants.

Skin-barrier reconstruction

Core functional proteins: EGF, bFGF, TGF-β, filaggrin, loricrin, ceramide synthase, HAS

Targets: Keratinocytes, broken brick-and-mortar sites of the stratum corneum

  1. Activates keratinocyte proliferation and differentiation, speeding complete stratum-corneum regeneration.
  2. Up-regulates filaggrin and loricrin and boosts ceramide and cholesterol synthesis to seal intercellular gaps.
  3. Activates HAS to produce hyaluronic acid, locking moisture in and reducing trans-epidermal water loss.
  4. Long-term structural-protein supply improves recurrent sensitivity, peeling and poor moisture retention.

Deep Hydration & Softening

Balance oil and moisture, boost skin water-locking capacity, soften rough skin and relieve flakiness

Same day

Skin becomes soft, dry and tight feeling disappears

3–5 days

Long-lasting hydration, no more flakiness

Over 2 weeks

Skin stays moisturized and smooth, superficial dry lines fade

How to use: Use twice daily. Combine with moisturizer for better results in dry environment.

Targeting principle & mechanism

Core functional proteins: bFGF, VEGF, HAS1/2/3, aquaporin AQP3, TGF-β

Targets: Keratinocytes, dermal fibroblasts, dermal microcirculation

  1. Up-regulates keratinocyte AQP3 water channels, improving the epidermis’s ability to draw in external moisture.
  2. Stimulates fibroblasts to secrete high-molecular-weight hyaluronic acid, filling dermal gaps for deep water storage.
  3. VEGF improves dermal microcirculation and the skin’s own water cycle, easing oily-but-dehydrated skin, flaking and dry lines.

Brightening & Even Tone

Accelerate skin metabolism, reduce pigmentation, brighten dull and sallow skin, even out skin tone

7 days

Sallowness and fatigue dullness fade

2–3 weeks

Skin tone becomes more uniform

Over 4 weeks

Skin gains natural radiance

How to use: Preferably use at night. **Must apply sunscreen in daytime**.

Targeting principle & mechanism

Core functional proteins: HGF, SOD, GSH (glutathione), TGF-β, tyrosinase-inhibiting protein, TRP-1-inhibiting peptide

Targets: Melanocytes, keratin-metabolising cells, dull / pigmented areas

  1. Directly inhibits tyrosinase and TRP-1 activity, blocking melanin synthesis.
  2. Clears UV / oxidative free radicals to prevent new melanin and improve sallow dullness.
  3. Speeds orderly keratinocyte turnover to shed melanin-laden dead cells for an even, clear complexion.
  4. Inhibits melanin transfer to the stratum corneum, fading post-inflammatory marks, sun spots and uneven tone.

Whitening & Radiance

Exosomes inhibit melanin production, block pigment transfer and accelerate skin metabolism. It gently fades dark tone, sallowness and sun tan, brightens skin from the inside without irritation or peeling

7 days

Skin looks less sallow, clearer and brighter

2–4 weeks

Melanin fades, sun tan and dull patches lighten

6–8 weeks

Skin tone becomes even, fairer and luminous

How to use: Best used at night. Daily sunscreen is mandatory to avoid pigment rebound. Avoid harsh peeling ingredients.

Targeting principle & mechanism

Core functional proteins: HGF, SOD, GSH (glutathione), TGF-β, tyrosinase-inhibiting protein, TRP-1-inhibiting peptide

Targets: Melanocytes, keratin-metabolising cells, dull / pigmented areas

  1. Directly inhibits tyrosinase and TRP-1 activity, blocking melanin synthesis.
  2. Clears UV / oxidative free radicals to prevent new melanin and improve sallow dullness.
  3. Speeds orderly keratinocyte turnover to shed melanin-laden dead cells for an even, clear complexion.
  4. Inhibits melanin transfer to the stratum corneum, fading post-inflammatory marks, sun spots and uneven tone.

Anti-Aging, Firming & Line Smoothing

Stimulate collagen and elastin production, lift sagging skin, reduce fine lines and wrinkles

1 week

Skin feels firmer, superficial dry lines soften

3–4 weeks

Fine lines fade, facial contour gets lifted

8–12 weeks

Skin elasticity improves significantly, aging slows down

How to use: Use consistently for long-term anti-aging effect. Apply on face and neck, reinforce on wrinkle areas.

Targeting principle & mechanism

Core functional proteins: TGF-β1/3, bFGF, VEGF, HGF, elastin, procollagen, MMP-1 inhibitors, HSP70

Targets: Dermal fibroblasts, elastic-fibre cells, photo-aged / aging areas

  1. Activates the TGF-β/Smad pathway to continuously generate collagen, elastin and fibronectin, thickening the dermis and firming sagging.
  2. Inhibits MMP-1 collagenase, reducing collagen loss and slowing skin laxity.
  3. VEGF boosts dermal blood supply, improving dullness from late nights, dry lines and static fine lines.
  4. Antioxidant repair of UV-induced cellular DNA damage, slowing photo-aging.
  5. Rebuilds the dermal–epidermal junction (DEJ), softening nasolabial folds, eye-area fine lines and laxity creases.

Acne Marks & Pit Repair

Speed up wound repair, fade red & dark acne marks, smooth shallow acne pits

5–7 days

New red acne marks fade rapidly

2–3 weeks

Dark marks lighten, skin texture gets smoother

4–6 weeks

Old marks and shallow pits are greatly improved

How to use: Spot apply on acne marks. Keep sun protection to avoid pigment rebound.

Targeting principle & mechanism

Red acne-mark repair

Core functional proteins: TGF-β3, VEGF, IL-10

Targets: Dermal capillaries, macrophages, inflamed red-mark areas

  1. Inhibits abnormal capillary proliferation, fading vascular dilation and redness.
  2. Clears residual inflammation, preventing red marks turning dark.
  3. Speeds local tissue repair, fading fresh red marks.

Dark acne-mark repair

Core functional proteins: HGF, SOD, GSH (glutathione), tyrosinase-inhibiting protein

Targets: Melanocytes, pigment-deposit areas

  1. Inhibits tyrosinase activity, blocking further melanin synthesis.
  2. Clears oxidative free radicals, preventing pigment deepening.
  3. Speeds turnover of melanin-laden keratinocytes, fading deposited dark marks.

Atrophic acne-scar repair

Core functional proteins: bFGF, TGF-β1, PDGF, type I/III procollagen, fibronectin, MMP inhibitors

Targets: Dermal fibroblasts, collagen-broken / deficient areas

  1. Activates abundant fibroblast proliferation to synthesise type I/III collagen and elastin.
  2. Secretes fibronectin to build the dermal ECM scaffold, filling depressions.
  3. Inhibits MMP metalloproteinases to prevent loss of new collagen.
  4. Balances TGF-β1/3 to avoid over-proliferation and hypertrophic scarring.

How exosomes target the skin

Core functional proteins: CD9 / CD63 / CD81 tetraspanins, integrins, ICAM adhesion proteins, chemokine receptor CXCR4

Targets: Full-thickness damaged / problem skin areas and their target cells

  1. Targeted recognition: the exosome membrane carries a molecular “postal code” that binds matching ligands on cells in the problem area, actively grabbing the lesion while barely retaining on healthy skin.
  2. Transdermal delivery: the 30–150 nm nanoscale matches stratum-corneum gaps; with its phospholipid bilayer it enters cells intact via both passive penetration and active endocytosis, without being broken down.
  3. Intracellular release: once inside the cell the membrane fuses and ruptures, releasing functional proteins that directly regulate cell genes and signalling pathways — improving skin from the root.

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